15 
X. PROPOSAL FX» APPROVAL OF SCHIZOSACCHAROMYCES POMBE FOR RECOMBINANT DNA 
EXPERIMEyrS 
Dr. Benj 2 BTiin Hall of the Lhiversity of Washington requested that the 
fission yeast, Schizosaccharonyces ponfce , together with cerevisiae/ 
E. ooli hybrid recpnbinant plaanids, be certified as ein HVl host-vector 
system (tabs 970, 975, 976/7). Dr. Hall in addition requested that this 
system be included in Section III-O of the Guidelines. Schizosaccharctnyces 
pqrbe is nonpathogenic, survives poorly outside of controlled laboratory 
conditions, is rare in nature, and exchanges genetic information only 
with other closely related organisms. E)r. Campbell said the request is 
unusued in that the specified host is the species rather than a specific 
laboratory strain. He noted that the current HVl certified hosts are at 
a selective disadvanteige relative bo their wild type counterparts. He 
felt the RAC should adhere to criteria specified in the Guidelines for 
certifying HVl host-vector systems. Ch this basis he said he could not 
recoirend approval of the request. Et. Gottesran agreed. 
Dr. Pinon agreed, but suggested that the NIH might permit certain experi- 
ments with the organian, while not certifying Schizoeaccharomyces pombe 
as an HVl host-vector system. 
Dr. Canpbell moved approval of the following motion: 
*C^ from nonpathogenic prokaryotes and lower eukaryotes may 
be cloned into Schiaosaccharomyces pombe ^%cies under PI 
containment conditions." 
By a vote of fourteen in favor, one opposed, and four abstentions RAC 
reccnmended the motion. Dr. Campbell then moved a second recamenda- 
tion: 
"D^A frcm higher eukaryotes may be cloned in Schizosaccharomyoes 
pombe species under P3 containment conditions?" 
By a vote of fourteen in favor, none opposed, and five abstentions, 
RAC accepted the motion. 
XI. REQUEST TO INCLUDE STREPTOCOCCUS FAECALIS AND SIREPTOCOCCUS SANGUIS UNDER 
EXEMPTION I-E-4. 
Dr. Gotteanan introduced the request (tabs 967, 976/1) of Dr. Donald 
Qe%«ll of the Dhiversity of Michigan that Streptococcus faecal is be 
included along vd.th Streptococcus sanguis in a sublist of Appendix A 
of the Guidelines. Dr. Gottesman notM that Appendix A currently has 
tvx5 sublists, E and F, both of which include Streptococcus sanguis . She 
suggested that Streptococcus faecalis be added to sublist F if the RAC 
is satisfied that the evidence demonstrates exchange in both directions 
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