Federal Register / Vol. 46, No. 54 / Friday. March 20, 1981 / Notices 
17991 
DEPARTMENT OF HEALTH AND 
HUMAN SERVICES 
National Inatitutea of Health 
Recombinant DNA Advisory 
Committee; Meetings 
Pursuant to Pub. L. 92-463, notice is 
hereby given of a meeting of the Large 
Scale Review Working Group sponsored 
by the Recombinant DNA Advisory 
Committee at the National Institutes of 
Health, Conference Room 7A24, Building 
31A, 9000 Rockville Pike, Bethesda, 
Maryland 20205, on April 22, 1981, from 
2 p.m. to 5 p.m. 
The Working Group will hold an 
organizational meeting to institute 
working procedures. 
Further information may be obtained 
from Dr. Elizabeth Milewski, Executive 
Secretary, Large Scale Review Working 
Group, NIAID, Building 31, Room 4A52, 
Bethesda, Maryland, telephone, (301) 
496-6051. 
The meeting will be open to the 
public. Attendance will be limited to 
space available. 
In addition, notice is hereby given of a 
meeting of the Recombinant DNA 
Advisory Committee at the National 
Institutes of Health, Conference Room 
10, Building 31C, 9000 Rockville Pike, 
Bethesda, Maryland 20205, on April 23, 
1981, from 9 a.m. to recess to 
approximately 6 p.m., and, if necessary, 
on April 24, 1981, from 8:30 a.m. to 5 pjn. 
This meeting will be open to the public 
on April 23 from 9 a.m. to approximately 
3 p.m., and on April 24 from 8:30 a.m. to 
adjournment to discuss: 
Amendment of Guidelines 
E. coli K-12 host-vector systems 
Host-vector systems other than E. coli 
K-12 
Risk-assessment 
Review of protocols for required 
containment levels 
Request for exception to a prohibition to 
clone genes of Foot and Mouth 
Disease Virus 
Containment levels for cloning of toxins 
Other matters requiring necessary 
action by the Committee. 
Attendance by the public will be limited 
to space available. 
In accordance with provisions set 
forth in Section 552b(c)(4), Title 5, U.S. 
Code and Section 10(d) of Pub. L. 92-463, 
the meeting will be closed to the public 
for approximately three hours for the 
review, discussion and evaluation of 
proposal(s) from a commercial 
concem(s) for scale-up of recombinant 
DNA experiments. It is anticipated that 
this will occur on April 23, from 
approximately 3 p.m. until adjournment. 
The proposal(s) and the discussion 
could reveal confidential trade secrets 
or commercial property such as 
patentable material. 
Dr. William J. Gartland, Jr., Executive 
Secretary, Recombinant DNA Advisory 
Committee, National Institutes of 
Health, Building 31, Room 4A52, 
telephone (301) 496-6051, will provide 
materials to be discussed at the meeting, 
rosters of committee members and 
substantive program information. A 
summary of the meeting will be 
available at a later date. 
Dated: March 9. 1981. 
Thomas E. Malone, Ph.D., 
Deputy Director, NIH. 
Note. — OMB's “Mandatory Information 
Requirements for Federal Assistance Program 
Announcements" (45 FR 39592] requires a 
statement concerning the official government 
programs contained in the Catalog of Federal 
Domestic Assistance. Normally NIH lists in 
its announcements the number and title of 
affected individual programs for the guidance 
of the public. Because the guidance in this 
notice covers not only virtually every NIH 
program but also essentially every Federal 
research program in which DNA recombinant 
molecule techniques could be used, it has 
been determined to be not cost effective or in 
the public interest to attempt to list these 
programs. Such a list would likely require 
several additional pages. In addition, NIH 
could not be certain that every Federal 
program would be included as many Federal 
agencies, as well as private organizations, 
both national and international, have elected 
to follow the NIH Guidelines. In lieu of the 
individual program listing, NIH invites 
readers to direct questions to the information 
address above about whether individual 
programs listed in the Catalog of Federal 
Domestic Assistance are affected. 
NIH programs are not covered by OMB 
Circular A-95 because they fit the description 
of "programs not considered appropriate" in 
Section 8(b) (4) and (5) of that Circular. 
(FR Doc. 81-8597 Filed 3-19-81; 8:45 am| 
BILLING CODE 4110-08-M 
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