4 
(1) Procedures to validate systems, e.g., how facility effluents are treated. 
Such information could be transmitted to communities in which plants utiliz- 
ing recombinant DNA technology are located. 
(2) Environmental monitoring in plant facilities. He felt that an inventory 
of current procedures might be a service to newcomers to the field and the 
experience of seasoned firms might be useful to these newcomers. 
(3) Risk assessments related to large-scale work should be performed and be 
available. He noted that most risk assessment to date has been performed 
with ^ coli K-12. However, industrial trends appear to be towards use of 
many other organisms as host-vector systems. He said that any important 
risk assessments performed by EPA or NIOSH should be available to the 
Large-Scale Review Working Group and to RAC. 
(4) Decisicxis of local IBCs concerning large-scale work. He said this is 
most difficult to conceptualize and suggested that the role and effective- 
ness of these IBCs in "self-monitoring" could be assessed. 
Dr. Mason suggested the working group define clearly the mission of the group. 
Dr. Bems called the attention of the ^oup to the rooticxi passed by the RAC at 
the September 25-26, 1980 meeting: 
"A large-scale review subcommittee of the RAC shall be established 
with the respcxisibility for advising the RAC on procedures and 
facilities design pertaining to large-scale operations, and on 
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