3 .. 
I. CALL TO ORDER AND CT>EHING REMARKS 
Mr. Thornton, Chairman, called the meeting to order at 9:00 a.m., on 
^>ril 23, 1981. He introduced the tvo ^ hoc cOTisultants v*io would parti- 
cipate in the session. Dr. Edward Melberg of Yede University and 
Dr. D. Michael Gill of Tufts Uhiversity. 
Mr. Hiomton said that the terms of several RAC members would expire with 
the /^il 1981 RAC meeting. Ihese mentoers are: Drs. Susan Qottesman, 
Allan Campbell, Luther Williams, Richard Novick, David Parkinson, Sheldon 
Krimsky, and Ms. Zelma Cason. Mr. Ihomton extended his personal ^preda- 
tion and the appreciation of the coranittee to the retiring members. 
Mr. Ihomton said a risk assessment protocol had been submitted to the NIH 
by Dr. Malcolm Martin of the NIH. He asked the Risk Assessment Subcommittee 
to evaluate the proposal. Dr. Gartland said that if the subcommittee 
approved the protocol, it would then be forwarded to the NIH Biosafety 
Oommitbee for evaluation. 
II. MINUTES OF THE JANUARY 8-9, 1981 MEETING 
Ms. Cason said she had reviewed the minutes (tab 1014) of the January 8-9, 
1981, meeting and found them to be correct. She moved acceptance of the 
minutes. Dr. Harris said she dso had reviewed the minutes and found them 
to be substantively accurate. 9ie seconded Ms. Cason's moticxi. Mr. Thornton 
noted that several typographical errors had been called to QRDA's attention. 
Dr. Bems said that a substantive phrase had been omitted from a statement 
attributed to him. (January 8-9, 1981 Meeting, Iton III. Meeting of the 
Institutional Biosafety Committee Chairpersons, page 6). He asked that this 
phrase be added to his statement cwi the proposed CDC Biosafety Guidelines 
for Etiological Agents (additional language in italics): 
"Dr. Bems said he found the CDC's p>roposed biosafety guidelines 
for etiological agents, with regard to some of the specific 
containment levels suggested , to be capricious and unscientific, 
and the CDC unresponsive to expressed concerns." 
Ms. Cason accepted, as an amendment, the propxjsed language. Mr. Thornton 
called for a voice vote, and the minutes of the January 8-9, 1981 meeting, 
as amended, were unanimously accepted. 
III. REPORT FROM DIRECTOR, NIAID 
Dr. Krause, the Director of National Institute of Allergy and Infectious 
Diseases (NIAID), said that the institute had recently been reorganized; 
as part of this reorganization, responsibility for risk assessment activi- 
ties in reccmhinant DNA had been transferred from the Office of Specialized 
Research and Facilities bo the Office of Recombinant ENA Activities. 
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