19 
recoibination anong heterologous pioomaviruses. He added that he knew of 
no human virus similar by nucleic acid hcmology to FMEV, but some rhino- 
viruses a^^ar to be similar structurally to fWEV. 
Dr. Goldstein asked that FMEV disease be described. Dr. Callis of the 
Plum Island Animal Disease Center said that the virus does not normally 
cause a high mortality in adult animals. FMIV causes death among young 
animals, but in adults causes weight loss and, as it infects secretory 
cells in the mamnary glands, disrupts milk production. Ihe disease spreads 
very, very rapidly and can infect every barnyard animal except the horse. 
Dr. Callis said that FWEV can chronically infect tissue culture systems 
and that many types of cells in culture, including primate cells, may be 
infected with FMEV. 
Dr. Bems said Genentech, Inc., had requested permission to perform this 
type of experiment at their facilities in South San Francisco. Noting 
that the laboratories at Plum Island were already working with v^ole FMEV, 
he moved to permit these experiments at Plum Island under P3 containment 
conditions. Ihe FMi:v genome between base pairs 500 and 4,100 may be cloned 
subject to the RAC Working Qraup evaluating individual experiments prior 
to their initiation. 
Dr. Ross asked if RAC could indicate v*iat sort of data it would require 
before it would allow transfer of the material from Plum Island to California 
for the production j*iase, should the tissue culture system be successful. 
Dr. Gottesman said that if the motion were adopted, and the work on Plum 
Island were successful, RAC would want to review these results before 
•approving transfer of material to California. 
Mr. Uiomton called the vote on Dr. Hems' motion. Ey a vote of seventeen 
in favor, none opposed, and one abstenticxi, RAC adc^ted the motion as follows: 
"Permission is granted in principle to propagate in mammalian 
cell culture recombinant DNA molecules consisting of segments 
of Foot and Mouth Disease Virus and SV40 deletion vectors under 
P3 conditions at the Plum Island Animal Disease Center. ;^proval 
of individual experiments is subject to review by a RAC Working 
Group." 
XI. CLOSED SESSION 
The RAC went into closed session to consider proposals fran commercial 
concerns for scale-up of reccmbinant DNA experiments. 
[108] 
