ATIACHMEM’ 2 - PAGE 4 
Question 3; The introduction of a toxin into the gut lumen may not 
accurately mimic the producticxi of the same amount of toxin by an 
organism. Ihus in the future, additional experiments may be needed 
to evaluate the actual risk from recombinant toxigenic organisms that 
colonize particular regions of the intestine. 
*Because the pig is an omnivore, its gut has a flora that resembles man's 
more than do other animals. For exanple, it has relatively high ^ ooli 
count. Further, coli strains suitable for secticxi 2 (b) are already 
available and diaracterized in piglets. 
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