3 
I. CALL TO ORDER AND OPENING REMARKS 
Mr. Ray Thorton, Chairman, called the meeting to order at 9:00 a.m., 
September 10, 1981. He welcomed five newly appointed members: Mr. Albert 
Daloz of Hancock, New Hanpshire; Dr. Arthur Landy of Brown IMiversity; 
Mr. Robert Mitchell of Norwalk, California; Dr. Mark Saginor of Los Angeles, 
California; and Dr. Pieter Wensink of Brandeis Ihiversity. Mr. Thornton 
noted that two other newly appointed roanbers. Dr. David Friedman of the 
University of Michigan Medical School and Dr. David Martin of the University 
of California, San Francisco, could not attend the September 10 and 11, 1981, 
meeting. 
Mr. Thornton, noting the resignation of Dr. Donald S. Fredrickson as 
Director of the National Institutes of Health, said the community would miss 
his counsel and leadership. Mr. Thornton said that Dr. Fredrickson had the 
great ability of clearly articulating the relationship between science and 
public policy. Mr. Thornton said that the RAC was fortunate, however, in 
that it would now report to Dr. Richard Krause, the Director of the National 
Institute of Allergy and Infectious Diseases, v^o has been delegated responsi- 
bility for recombinant ENA matters. In introducing Dr. Krause, Mr. Thornton 
said the RAC has developed great confidence in his professional and scientific 
judgement. 
Dr. Krause extended his welcome to the newly appointed members of the com- 
mittee. He called the attention of the RAC to tab 1021, in v^ich 
Dr. Fredrickson had delegated to Dr. Krause responsibility for actions under 
the NIH Guidelines for Research Involving Reconbinant K^A Molecules. 
II. MINUTES OF THE APRIL 23-24, 1981 MEETING 
Dr. Mason began the review of the minutes of the ^ril 23-24, 1981, RAC meet- 
ing by commending those responsible for the minutes. He pointed out a typo- 
graphical error in Section X of those minutes. He moved approval of the 
minutes as written, subject to any corrections or modifications members of the 
Corrmittee might wish to forward to the Executive Secretary. Dr. Scandalios 
concurred and seconded the motion. By a voice vote, the motion was unanimously 
carried. 
III. PROPOSED REVISION OF THE GUIDELINES 
Drs. David Baltimore and Allan Campbell, RAC members, had proposed a major 
revision of the Guidelines (Baltimore-Campbell proposal. Attachment II) v^ich 
was ccMisidered by the RAC at its April 23-24, 1981 meeting. At the i^ril 1981 
meeting, a Working Group on Revision of the Guidelines was established to 
review the Baltimore-Campbell prc^sal as well as other approaches v^ich might 
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