5 
IV-D of the Guidelines. While the Baltimore-Canpbell proposal retains the 
prciiibition section of the Guidelines (I-D), the Working Group proposal 
eliminates the prohibitions on the loasis that currently prc*iibited experiments 
would be prereviewed by an IBC in their proposal. Dr. Gottesman said that she 
felt that the major issues for discussion are; prohibitions, prereview of 
covered experiments, and containment levels. 
Dr. Bems noted that five Working Group roanbers, including himself, submitted 
a minority report v^ich disagrees with the Working Group's pr<^»sal to retain 
the mandatory nature of the Guidelines. Hie minority report recommends 
elimination of Part IV of the Guidelines. 
Dr. Goldstein said that he agrees with parts of the Wbrking Group report. He 
said that IBCs are still needed although a survey in California has indicated 
great variation in IBCs. He also said that prohibited experiments need to be 
more clearly considered. 
Dr. Harris said that she felt that the Working Group's report is an acceptable 
oonpronise . 
Ms. King said that the report suggests a direction for movement but that 
details need to be worked out. She said that if there are Guidelines, there 
should be sanctions. She said that distinguishing NIH grantees from non- 
grantees is not unique; she cited the situation with human experimentation. 
Ms. King said that she strongly favors retention of the sanctions. 
Dr. Nightingale said that she supports the recommendations of the Working 
Group, saying that they represent a good compromise. She expressed ooncem 
about the availability of other guidelines cited in the Working Group report. 
In this regard, she noted the many comments received on the proposed CDC Bio- 
safety Guidelines for Microbiological and Biomedical Laboratories. She also 
expressed ooncem that prohibition I-D-4, dealing with deliberate release into 
the environment, had not been dealt with. Dr. Nightingale said there is a 
necessity for accountability vhen public funds are being used. She said 
the PAC needs an assessment of outside perceptions and that the background 
document needs further work. 
Dr. Zinder then addressed the RAC. He noted that he had prepared the minority 
reports to the Working Group's recommendations. He said that although there 
is a disagreement about the administrative aspects of the Guidelines, there 
was unanimity in the Working Group in favor of the new proposed containment 
levels. He noted that alttough inclusion of a slightly modified Part IV was 
reocxTtmended by the Working Group, five members have now endorsed a minority 
report stating that Part IV should be removed frcm the Guidelines. Drs. 
Adelberg and Zinder also signed a second minority report recommending complete 
elimination of the Guidelines. Dr. Zinder said that he and the scientists 
concerned about recombinant DNA originally proposed guidelines v^ich would 
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