9 
'I-A, Purpose . Tlie purpose of these Guidelines is to specify 
standard practices for constructing and handling (i) recombinant 
DNA molecules and (ii) organisms and viruses containing 
recombinant DNA molecules. Adherence to these standards by 
all laboratories using recombinant DNA is recommended . ' " 
2. Accept the second section of the Baltimore-CamE±>ell proposal, as follows: 
"Part I~C of the NIH Guidelines shall be eliminated." 
3. Accept the second section of the Working Group proposal, as follows: 
"Section I-D of the Guidelines, Prohibitions , would be 
eliminated." 
4. Accept the third section of the Working Group report modified by removing 
references to CDC Guidelines and USDA Regulations and treating these 
references in a footnote, as follows: 
"Part III of the Guidelines would be replaced with the following 
language: 
'Part III discusses experiments covered by the Guidelines. 
The reader should first consult Part I, where exenpt experi- 
ments are listed. 
'Where recommended physical containment levels applicable to 
non-recombinant DNA experiments exist for either the host or 
the vector*, recombinant ENA experiments should be carried out 
at containment levels at least as high as those recommended 
for non-reoombinant DNA experiments. If there is clear 
evidence that the donor KIA will significantly change the 
pathogencity of the host, the containment level appropriate 
to the anticipated change will be applied. Otherwise, all 
experiments may be carried out under conditions of PI or Pl-LS 
physical containment.'" 
5. Ihe following admonition would be added: 
"No experiments should be performed which involve deliberate 
transfer of a drug resistance trait to microorganisms that are 
not known to acquire it naturally, if such acquisition could 
compromise the use of a drug to control disease agents in human 
or veterinary medicine or agriculture." 
6. Accept the fourth section of the Baltimore-Campfeell proposal, as follows: 
*Such as those specified by CDC Guidelines or the USDA Quarantine Regulations. 
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