Attachment II - Page 2 
PHC*>OSAL TO OONVERT THE NIH GUIDELINES INTO A NON-REGUIATORY CODE OF 
STANTARD PRACTIVE WD TO REDUCE TOE RECOMMENDED CONTAirWENT IZVELS FOR SOME 
EXPERIMEJ7TS 
PROPOSAL 
1) Section I-A of the NIH Guidelines will be replaced with the following: 
"I-A. Purpose . TOe purpose of these Guidelines is to specify standard 
practices for constructing and handling (i) recombinant DMA molecules and 
(ii) orgemisms and viruses containing recombinant DNA molecules. Adherence 
to these standards by all laboratories using recombinant CNA is reconmended." 
2) Part I-C of the NIH Guidelines shall be eliminated. 
3) Part III of the Guidelines will be replaced with the following; 
"Part III discusses experiments covered by the Guidelines. TOe reader 
must first consult Part I, v*iere listings are given of prohibited and exenpt 
experiments. 
"Where there are existing recommended physical containment levels 
applicable to non-recombinant DNA experiments with either the host or the 
vector (such as those specified by the CDC Guidelines), recombinant CNA 
experiments should be carried out at containment levels at least as high as 
those reconmended for non-reocmbinant CNA experiments. Otherwise, all non- 
prohibited experiments may be carried out under conditions of Pi physical 
containment. As a general practice, investigators should use the highest 
level of biologiceil containment (HV3>HV2>HV1 ) which is available and 
appropriate for the purposes of the experiment. 
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