Federal Register / Vol. 46, No. 233 / Friday, December 4, 1981 / Notices 
59425 
.i. Containment Conditions for Cloning 
of Toxins Genes in Organisms Other 
Than E. coli K~12 
Requests involving the cloning of 
genes coding for toxins for vertebrates 
in host-vector systems other than E. coli 
K-12 will be evaluated by ORDA, which 
will consult with the ad hoc working 
group on toxins. (See Section IV-E-l-b- 
(3Hi)-) 
Appendix H of Annex E. — Experiments 
Covered by Section III-O 
No experiments currently fall under 
Section III-O of the Guidelines. 
Note. — OMB’s ‘Mandatory Information 
RKC)uircnients for Federal Assistance Program 
Announcements" (45 FR 39592] requires a 
stiilemcnl concerning the official government 
programs contained in the Catalog of Federal 
Domes! n Assistance. Normally NIH lists in 
Its announcements the number and title of 
affected individual programs for the guidance 
of the public. Because the guidance in this 
notice covers not only virtually every NIH 
program hut also essentially every federal 
research program in which DNA recombinant 
molecule techniques could be used, it has 
been dotennined to be not cost effective or in 
the public interest to attempt to list these 
programs. Such a list would likely require 
several additional pages. In addition, NIH 
could not be certain that every federal 
program would be included as many federal 
agencies, as well as private organizations, 
both national and inteniatinnal, have elected 
to follow the NIH Guidelines. In lieu of the 
individual program listing, NIH invites 
readers to direct questions to the information 
address above about whether individual 
programs listed in the Catalog of Federal 
Domestic Assistance are affected. 
NIH programs are not covered by OMB 
Circular A-95 because they fit the description 
of "programs not considered appropriate” in 
Section 8-(bH4] and (5) of that Circular. 
Dated: October 26. 1981. 
Richard M. Krause, 
Director, National Institute of Allergy and 
Infectious Diseases. 
(FR Uoc, 81 -a446» Filed 12-3-ni. 8:45 nm) 
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