732 
Federal Register / Vol. 47, No. 3 / Wednesday, January 6, 1982 / Notices 
DEPARTMENT OF HEALTH AND 
HUMAN SERVICES 
National Institutes of Health 
Recombinant DNA Advisory 
Committee; Meetings 
Pursuant to Pub. L. 92-463, notice is 
hereby given of a meeting of the 
Recombinant DNA Advisory Committee 
at the Marriott Hotel, Salon D and E, 
5151 Pooks Hill Rd., Bethesda, Maryland 
20014, on February 8, 1982, from 9:00 
a.m. to recess at approxirhately 6:00 
p.m., and, if necessary, on February 9, 
1982, from 8:30 a.m. to 5:00 p.m. This 
meeting will be open to the public to 
discuss; 
Proposed major revision of Guidelines 
Amendment of Guidelines 
E. coli K-12 host-vector systems 
Host-vector systems other than E. co// K-12 
Risk-assessment 
Review of protocols for required containment 
levels 
Proposed exemptions to Guidelines 
Other matters requiring necessary action by 
the Committee 
Attendance by the public will be 
limited to space available. 
Dr. William J. Gartland, Jr., Executive 
Secretary, Recombinant DNA Advisory 
Committee, National Institutes of 
Health, Building 31, Room 4A52, 
telephone (301) 496-6051, will provide 
materials to be discussed at the meeting, 
rosters of committee members, and 
substantive program information. A 
summary of the meeting will be 
available at a later date. 
In addition, notice is hereby given of a 
meeting of the Large Scale Review 
Working Group sponsored by the 
Recombinant DNA Advisory Committee 
at the National Institutes of Health, 
Building 31C, Conference Room 8, 9000 
Rockville Pike, Bethesda, Maryland 
20205, on February 9, 1982, after 
adjournment of the meeting of the 
Recombinant DNA Advisory Committee, 
from approximately 2:00 p.m. to 5:00 p.m. 
The meeting will be open to the public. 
Attendance will be limited to space 
available. 
Further information may be obtained 
from Dr. Elizabeth Milewski, Executive 
Secretary, Large Scale Review Working 
Group, NIAID, Building 31, Room 4A52, 
Bethesda, Maryland, telephone (301) 
496-6051. 
Note. — OMB’s "Mandatory Information 
Requirements for Federal Assistance Program 
Announcements" (45 FR 39592) requires a 
statement concerning the official government 
programs contained in the Catalog of Federal 
Domestic Assistance. Normally NIH lists in 
its announcements the number and title of 
affected individual programs for the guidance 
(j)f the public. Because the guidance in this 
notice covers not only virtually every NIH 
program but also essentially every federal 
research program in which DNA recombinant 
molecule techniques could be used, it has 
been determined to be not cost effective or in 
the public interest to attempt to list these 
programs. Such a list would likely require 
several additional pages. In addition, NIH 
could not be certain that every federal 
program would be included as many federal 
agencies, as well as private organizations, 
both national and international, have elected 
to follow the NIH Guidelines. In lieu of the 
individual program listing, NIH invites 
readers to direct questions to the information 
address above about whether individual 
programs listed in the Catalog of Federal 
Domestic Assistance are affected. 
NIH programs are not covered by OMB 
Circular A-95 because they fit the description 
of "programs not considered appropriate” in 
section 8-(b)-(4) and (5) of that Circular. 
Dated: December 22. 1981. 
Thomas E. Malone, 
Deputy Director, NIH. 
(FR Doc. 82-21 Filed 1-5-82; 8:45 am] 
BILLINQ CODE 4140-01-M 
Recombinant DNA Research; 
Proposed Actions Under Guidelines 
agency: National Institutes of Health, 
PHS, HHS. 
ACTION: Notice of actions under NIH 
Guidelines for Research Involving 
Recombinant DNA Molecules. 
SUMMARY: This notice sets forth 
proposed actions to be taken under the 
NIH Guidelines for Research Involving 
Recombinant DNA Molecules. 
Interested parties are invited to submit 
comments concerning these proposals. 
After consideration of these proposals 
and comments by the NIH Recombinant 
DNA Advisory Committee (RAC) at its 
February 8-9, 1982 meeting, the Director 
of the National Institutes of Health will 
issue decisions on these proposals in 
accord with the Guidelines. 
date: Comments must be received by 
February 5. 1982. 
ADDRESS: Written comments and 
recommendations should be submitted 
to the Director, Office of Recombinant 
DNA Activities, Building 31, Room 4A52, 
National Institutes of Health, Bethesda, 
Maryland 20205. All comments received 
in timely response to this notice will be 
considered and will be available for 
public inspection in the above office on 
weekdays between the hours of 8:30 
a.m. and 5:00 p.m. 
FOR FURTHER INFORMATION CONTACT: 
Background documentation and 
additional information can be obtained 
from Drs. Stanley Barban or Elizabeth 
Milewski. Office of Recombinant DNA 
Activities, National Institutes of Health, 
Bethesda, Maryland 20205, (301) 496- 
6051. 
SUPPLEMENTARY INFORMATION: The 
National Institutes of Health will 
consider the following actions under the 
Guidelines for Research Involving 
Recombinant DNA Molecules. 
1. Request for Permission to Clone 
Subgenomic Segments of Foot and 
Mouth Disease Virus 
Molecular Genetics, Inc., of 
Minnetonka, Minnesota, requests 
approval to transfer E. coli K-12 cDNA 
clones comprising less than 75% of the 
entire genome of Foot and Mouth 
Disease Virus from the Plum Island 
Animal Disease Center to its research 
facility at 10320 Bren Road East, 
Minnetonka, Minnesota, and to conduct 
experiments with these clones under PI 
containment conditions. 
2. Request to Clone Plant DNA in the 
Cyanobacterium Anacystis Nidulans 
Dr. Lawrence Bogorad of Harvard 
University requests permission to 
initiate, at Pi containment, a program 
involving the cloning in the 
cyanobacterium Anacystis nidulans 
(strain R2) of DNA from chloroplasts of 
various plants (initially primarily from 
Zea mays). Dr. Bogorad would employ 
the plasmid vector pUCl04, a construct 
of the cyanobacterial plasmid pUCl and 
the E. coli vector pACYCl84. 
Note. — OMB’s "Mandatory Information 
Requirements for Federal Assistance Program 
Announcements" (45 FR 39592) requires a 
statement concerning the official government 
[ 326 ] 
