MINITTES CF THE MEETDG, FEBRJAPY 9, 1982 
lARS-SCAIf; REVIEW MORKING GROUP 
Dr. Bems of the Ihiversity of Florida called the third meeting of the 
Large-Scale Review Vlor)d.ng Qrojqp to order at 2:05 p.m. on Pebrmry 9, 1982. 
Dr. Mason of the Utah State Department of Health reviewed the minutes of the 
September 9, 1981 meeting of the working group. He said the minutes were 
sibstantively correct ard moved epprovad with conmendation. The minutes 
of the September 9 meeting were unanimously accepted. 
Dr. Bems then introduced Ck:. Riilip landrigan of the National Institute fior 
Occupatiorud Safety and Health (NIOGH). Or. Bems said Dr. landrigan had 
agreed to present to the Large-Scale Review Viorking Gboup the CDC/^IOSH draft 
report on Medical Surveillance for Industrial Applications of Recombinant 
IKA. Cr. Bems said the OXT/NIGSH report was in part a response to a RAC request 
to discuss medical surveillanoe problems. 
Dr. Landrigem introduced other NI06H r^resentatives: Dr. Elliot Harrisr the 
Deputy Director of NI06H, Mr. larry Elliott, an industrial hygenist who had 
participated in NICSH's "walk-through" of six oonpanies invol\«d in reconbinant 
DTA technology, and Ms. Steph^ulie Soucek. He also introduced Cr. John Ridiardson 
of the Centers for Disease Control (CDC). 
Dr. landrigan then distributed to the working group a revised version of the 
CDC/NIQ6H report (Attachment I). He suggested the report was an exercise in 
"future forecasting", but argued that past experience might reasonably be 
used to predict potential hazards to workers as reocmbinant ENA techniques 
are transferred bo the industrial setting. He said the CDC/^IOSH group had 
reviewed processes involved in the production, by reoanbin^mt INA tedinlques. 
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