Federal Register / Vol. 47, No. 77 / Wednesday, April 21, 1982 / Notices 
17195 
Mycoplasma — alj species except 
Mycoplasma mycoides and Mycoplasma 
agalactiae, which are in Class 5 
Neisseria gonorrhoeae, N. Meningitidis 
PasteurelJa — all species except those listed in 
Class 3 
Salmonella — all species and all serotypes 
Shigella — all species and all serotypes 
Sphaerophorus necrophorus 
Staphylococcus aureus 
Streptobacillus moniliformis 
Streptococcus pyogeiies 
Treponema carateum, T pallidum, and T. 
pertenue 
Vibrio fetus, V. comma, including biotype El 
Tor, and Vi parahemolyticus 
2. Fungal Agents 
**Actinomycetes (including Nocardia species 
and Actinomyces species and Arachnia 
propionica) 
Blastomyces dermatitidis 
Cryptococcus neoformans 
Paracoccidioides brasiliensis 
3. Parasitic Agents 
Endamoeba histolytica 
Leishmania sp. 
Naegleria gruberi 
Toxoplasma gondii 
Toxocara canis 
Trichinella spiralis 
Trypanosoma cruzi 
4. Viral, Rickettsial, and Chlamydial 
Agents 
Adenoviruses — human — all types 
Cache Valley virus 
Coxsackie A and B viruses 
Cytomegaloviruses 
Echoviruses — all types 
Encephalomyocarditis virus (EMC) 
Flanders virus 
Hart Park virus 
Hepatitis-associated antigen material 
Herpes viruses — except Herpesvirus simiae 
(Monkey B virus) which is in Class 4 
Corona viruses 
Influenza viruses — all types except A/PR8/ 
34, which is in Class 1 
Langat virus 
Lymphogranuloma venereum agent 
Measles virus 
Mumps virus 
Parainfluenza virus — all types except 
Parainfluenza virus 3, SF4 strain, which is 
in Class 1 
Poliviruses — all types, wild and attenuated 
Poxviruses — all types except Alastrim, 
Smallpox, Monkey pox, and Whitepox, 
which depending on experiments, are in 
Class 3 or Class 4 
Rabies virus — all strains except Rabies street 
virus, which should be classified in Class 3 
when inoculated into carnivores 
Reoviruses — all types 
Respiratory syncytial virus 
Rhinoviruses — all types 
Rubella virus 
Simian viruses — all types except Herpesvirus 
simiae (Monkey B virus) and Marburg 
virus, which are in Class 4 
Sindbis virus 
Tensaw virus 
Turlock virus 
Vaccinia virus 
Varcella virus 
Vole rickettsia 
Yellow fever virus, 17D vaccine strain 
C. Class 3 Agents 
1. Bacterial Agents 
Actinobacillus mallei* 
Bartonella — all species 
Brucella — all species 
Francisella tularensis 
Mycobacterium avium, M. bovis, M. 
tuberculosis 
Pasteurella multocide type B ("buffalo" and 
other foreign virulent strains*) 
Pseudenionas Pseudomallei* 
Yersenia pestis 
2 . Fungal Agents 
Coccidioides immitis 
Histoplasma capsulatum 
Histoplasma capsulatum var. duboisii 
3. Parasitic Agents 
Schistosoma mansoni 
4. Viral, Rickettsial, and Chlamydial 
Agents 
***Alastrim, Smallpox, Monkeypox, and 
Whitepox, when used in vitro 
Arboviruses — all strains except those in 
Class 2 and 4 (Arboviruses indigenous to 
the United States are in Class 3, except 
those listed in Class 2. West Nile and 
Semliki Forest viruses may be classified up 
or down, depending on the conditions of 
use and geographical location of the 
laboratory.) 
Dengue virus, when used for transmission or 
animal inoculation experiments 
Lymphocytic choriomeningitis virus (LCM) 
Psittacosis-Ornithosis-Trachoma group of 
agents 
Rabies street virus, when used in 
inoculations of carnivores (See Class 2) 
Rickettsia — all species except Vole rickettsia 
when used for transmission or animal 
inoculation experiments 
Vesicular stomatitis virus * 
Yellow fever virus — wild, when used in vitro 
D. Class 4 Agents 
1. Bacterial Agents: None 
2. Fungal Agents: None 
3. Parasitic Agents: None 
4. Viral, Rickettsial, and Chlamydial 
Agents 
* * *Alasatrim, Smallpox, Monkey pox, and 
Whitepox, when used for transmission or 
animal inoculation experiments 
Hemorrhagic fever agents, including Crimean 
hemorrhagic fever, (Congo), /unin, and 
Machupo viruses, and others as yet 
undefined 
Herpesvirus simiae (Monkey B virus) 
Lassa virus 
Marburg virus 
Tick-borne encephalitis virus complex, 
including Russian spring-summer 
encephalitis, Kyasanur forest disease, 
Omsk hemorrhagic fever, and Central 
European encephalitis viruses 
Venezuelan equine encephalitis virus, 
epidemic strains, when used for 
transmission or animal inoculation 
experiments 
Yellow fever virus — wild, when used for 
transmission or animal inoculation 
experiments 
II. Classification of Oncogenic Viruses on the 
Basis of Potential Hazard (2) 
A. Low-Risk Oncogenic Viruses 
Rous Sarcoma 
SV-40 
CELO 
Ad7-SV40 
Polyoma 
Bovine papilloma 
Rat mammary tumor 
Avian Leukosis 
Murine Leukemia 
Murine Sarcoma 
Mouse mammary tumor 
Rat Leukemia 
Hamster Leukemia 
Bovine Leukemia 
Dog Sarcoma 
Mason-Pfizer Monkey Virus 
Marek's 
Guinea Pig Herpes 
Lucke (Frog) 
Adenovirus 
Shope Fibroma 
Shope Papilloma 
B. Moderate-Risk Oncogenic Viruses 
Ad2-SV40 
FeLV 
HV Saimiri 
EBV 
SSV-1 
GaLV 
HV a teles 
Yaba 
FeSV 
III. Animal Pathogens (3) 
A. Animal disease organisms which are 
forbidden entry into the United States by 
Law (CDC Class 5 agents) 
1. Foot and mouth disease virus 
B. Animal disease organisms and vectors 
which are forbidden entry into the 
United States by USDA Policy (CDC 
Class 5 Agents) 
African horse sickness virus 
African swine fever virus 
Besnoitia besnoiti 
Borna disease virus 
Bovine infectious petechial fever 
Camel pox virus 
Ephemeral fever virus 
Fowl plague virus 
Goat pox virus 
Hog cholera virus 
Louping ill virus 
Lumpy skin disease virus 
Nairobi sheep disease virus 
Newcastle disease virus (Asiatic strains) 
Mycoplasma mycoides (contagious bovine 
pleuropneumonia) 
Mycoplasma agalactiae (contagious agalactia 
of sheep) 
Rickettsia ruminatium (heart water) 
Rift valley fever virus 
Rinderpest virus 
Sheep pox virus 
Swine vesicular disease virus 
Teschen disease virus 
Trypanosoma vivax (Nagana) 
Trypanosoma evansi 
Theileria prava (East Coast fever) 
Theileria annulata 
Theileria lawrencei 
Theileria bovis 
Theileria hirci 
Vesicular exanthema virus 
Wesselsbron disease virus 
Zyonema 
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