11 
chronosomal exchange. Er. Friednan added that Dtr. Dunny's data show only 
that an antibiotic resistance gene carried by a plasmid is expressed by 
the recipient species. Dr. Friedman then noved that Dr. Dunny's request 
to include S. agalactiae in /^pendix A, Sublist F, be denied; he suggested 
that Dr. Dunny be informed that PI conditions are indicated under the cur- 
rent Guidelines. Dr. Wensirik seconded the motion. By a vote of twenty 
in favor, none opposed, and no abstentions, the motion to deny Dr. Dtnny's 
request was carried. 
V. PROPOSED REVISIOJ OF THE GUIDELINES 
Dr. Nightingale began discussion of the modifications (tabs 1071, 1072, 
1074) to the Guidelines proposed by the Working Group on Revision of the 
Guidelines. She recalled to the conmittee that the RAC at its February 
8-9, 1982, meeting recommended that NIH accept a proposed modification 
of the NIH Guidelines for Research Involving Recombinant ENA Molecules. 
In recommending this modification to the NIH, the committee reconmended 
that a working group be formed to further simply and modify the document. 
Ihe NIH, following this recommendation, promulgated the Revised Guidelines 
on /^il 21, 1982. An ^ hoc Working Group on Revision of the Guidelines 
was formed and convened for a meeting on April 19, 1982, to further modify 
the document promulated on ^^il 21, 1982. Dr. Nightingale said the working 
group attempted to clarify and simplify, vherever possible, the structure 
and language of the Guidelines, to suggest dianges appropriate in light 
of available data, and to recommend future activities in the area of guide- 
line review and revision. 
Dr. Nightingale then indicated four major proposed modifications offered by 
this working group. First, the working group had suggested the presentation 
of the Guidelines be rearranged primarily by placing the description of f^s- 
ical and biological containment into appendices. Second, the working group 
recommended that the RAC and NIH adept for the Guidelines a revised version 
of the 1974 CDC Classification of Etiologic Agents on the Basis of Hazard . 
Ihe working group also suggested that the RAC assume responsibility for 
regularly updating the listing. Dr. Nightingale explained that the original 
1976 Guidelines used the Classification of Etiologic Agents on the Basis 
of Hazard , 4th Edition, July 1974, U.S. Department of Health, Education, 
and Welfare, Public Health Service, Center for Disease Control (CDC), as 
the reference source for classification of microorganisms for the purposes 
of the Guidelines. At the present time, the CDC and the NIH are engaged 
in an effort to revise this classification. The working group, however, 
felt that this revised version might not serve the purposes of the Guide- 
lines as well as the original 1974 version as revised. Dr. Nightingale 
said this is the only proposal of the working group that received a letter 
of conment. Dr. Berns said he wished to reply to an issue raised by 
Dr. John Richardson of the CDC in a letter of June 10, 1982 (tab 1074), 
concerning the proposed revision of Appendix B for the purposes of the 
NIH Guidelines. Dr. Bems said the proposed revised classification would 
classify Rabies street virus as a Class 3 agent for all procedures. 
[470] 
