15 
Dr. Brill questioned the inclusion of all Klebsiella strains as Class 2 
agents in ^pendix B. He said Klebsiella species are ubiquitous. Dr. Berns 
pointed out that Klebsiella was classified as Class 2 in the original 1974 
edition of the Classification of Etiologic Agents ; the workir^ group had 
not changed its classification. Dr. Holines said he could suggest several 
nodifications to ^pendix B: he agreed with Dr. Richardson that Schistosoma 
mansoni should be Class 2; the Psittacosis-Omithosis-Traciioma group needs 
to be revised; consideration shDuld be given to grouping Mycobacterium 
leprae with Myccteacterium tuberculosis . Mr. Thornton suggested that a 
working group review the /^pendix B list and r^xDrt to the RAC at its next 
meeting. The committee agreed. 
Dr. Nightingale reviewed the proposed changes in Section IV, Roles and 
Responsibilities . These modifications include: 
(1) in Section IV-B-2, language was inserted to the effect 
that the IBC's "responsibilities need not be restricted 
to reccmbinant ENA," 
(2) in Section IV-B-2-a, the requirement was deleted that 20 
percent of the IBC membership not be affiliated with the 
institution (although the requirement was retained that 
at least twc IBC members not be affiliated with the 
institution), and 
(3) in Section IV-B-2-b, language reccmmend ing that "at least 
one member be a nondoctoral person from a laboratory tech- 
nical staff" was modified to read "at least one member be 
fron the laboratory technical staff." 
Dr. Bems commented on the proposal to delete the word "nondoctoral". He 
said some members of the working group felt a "nondoctoral" technician 
with actual "hands-on" experience was most appropriate for this "slot" 
on the IBC. 
Other members felt that anyone who had "hands on" experience and vho was 
not a principal investigator (including technician, research associate, or 
post-doctoral fellow) was an apprcpriate representative of the laboratory 
technical staff. Following much discussion, the term "nondoctoral" had 
been deleted from the proposed revised Guidelines by the working group. 
Dr. Ahmed questioned why the requirement was deleted that 20 percent of the 
IBC membership be non-af filiated with the Institution. Dr. Berns offered 
the example of an IBC just fulfilling the 20 percent specification, but 
wishing to add an additional specialist affiliated v/ith the university. 
When this specialist was appointed, non-af filiated representation would fall 
below 20 percent, and the university would have to ^point another non- 
af filiated member. Dr. Berns said the working group felt the percentage 
of non-af filiated members was not critical as long as two non-af filiated 
members were present on the IBC. Dr. Ahmed pointed out that on an IBC 
[474] 
