4 . The 10 Liter Limit . 
Our membership has no problems with 10 liters as the 
boundary between large and small scale experiments. We do feel 
that 10 liters is an arbitrary boundary and certainly does not 
reflect industry practice. Most industrial pilot plant opera- 
tions, for example, take place at the 250-3,000 liter size. As 
additional experience is accumulated with industrial applica- 
tions, we think the committee will find it logically compelling 
to adjust the large-sqale threshold upward. 
5 . Medical Monitoring . 
Virtually all of our members have instituted medical 
surveillance programs. Common to most of these programs are 
medical check-ups, storage of serum samples and follow-ups in 
cases of extended or serious illnesses. Since the IBCs through 
the institutions are charged with the task of reviewing medical 
monitoring programs as part of their obligations under the 
Guidelines, these programs can be supplemented by the IBC in the 
case of particular experiments. Thus, if any special 
requirements are appropriate in the case of a particular 
experiment, the IBC can require a special program of medical 
monitoring. We think this approach is most reasonable and 
recommend its continuance. 
A number of our members question the need for any 
medical surveillance program directed toward recombinant DNA 
experimentation specifically since there is no evidence of any 
hazard unique to rDNA experimentation. Moreover, it is widely 
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