THE UNIVERSITY OF KANSAS MEDICAL CENTER 
COLLEGE OF HEALTH SCIENCES AND HOSPITAL 
RAINBOW BOULEVARD AT 39TH • KANSAS CITY, KANSAS 66103 
SCHOOL OF MEDICINE 
SCHOOL OF NURSING 
SCHOOL OF ALLIED HEALTH 
UNIVERSITY HOSPITAL 
December 22, 1^80 
SCHOOL OF MEDICINE 
DEPARTMENT OF MICROBIOLOGY 
(SIS) MS-70I0 
Dr. William Cart i and 
Office of Recombinant DNA activities 
National Institute of General Medical Science 
National Institute of Health 
Building 31 i Room 4A52 
Bethesda, Maryland 20014 
Dear Dr, Gartland; 
I should like to write in support of Dr. Winston Brill's proposal 
that all experiments with nonpathogen i c procaryotes and lower eucaryotes 
be permitted under P-1 containment (Federal Register, November 28, 1980). 
My particular interest involves Neurospora crassa . 
Experiments that we are now contemplating, involving the use of chimeric 
E coii/yeast plasmids in Neurospora , would require P-2 facility. Given 
the fact that Neurospora is a pathogen neither for man nor his crops; the 
expense and time delay involved In building a P-2 facility seems unjustified. 
I am sure that many people working with non-pathogen ic lower eucaryotes 
are in a similar position. Relaxation of this overly stringent regulation 
would doubtless have a very beneficial effect on research with these 
organ i sms . 
Sincerely, 
John A. Kinsey, Ph.D. 
Microbiology 
JAK: jlw 
1553] 
