^iikr ^cMcal OUentrr 
DURHAM. NORTH CAROLINA 
177 10 
OCFARTMCNT OF BIOCHEMISTRY 
December 23, 1980 
Director 
Office of Recombincint DNA Activities 
Building 31, Room 4A52 
National Institutes of Health 
Bethesda, Maryland 20205 
I would like to support Dr. Winston Brill's proposal that the 
Recombinant DNA Guidelines be amended to permit recombinant DNA 
experiments involving nonpathogenic prokaryotes and lower eukaryotes 
under PI containment conditions. It would be helpful to eliminate 
impediments to recombinant DNA research using organisms such as 
Neurospora which offer practically no conceivable danger to man or 
to his environment. Many of us are convinced that organisms such 
as Neurospora , Yeast and other lower eukaryotes will provide host 
vector systems that are less likely to present a biological hazard 
than organisms that now can be handled under PI conditions. 
Sir: 
Samson R. Gross U 
Professor of Genetics and Biochemistry 
SRG:dh 
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