OdiieFOODSa 
M5-1711 
MASSACHUSETTS INSnTUTE OF TECHNOLOGY 
Cambridge, Massachusetts 02139 
U,S^. 
I 
Department of Nutrition and Food Science 
56-123 
• Anwid LOemain 
j P ro faa or d 
I Industrial Microbiology 
March 24, 1981 
Dr. Elizabeth Milewski 
Bldg. 31, Rocm4A52 
ORDA-NIH 
Bathesda, MD 20205 
Dear Dr. Milewski : 
I would like to support the request of Dr. Donald 
H. Dean to ease the restrictions on using Bacillus subtil is 
for recombinant DNA experiments. This organism and its 
dose relatives hBvek>een used widely in industry for both 
research and production. To my knowledge, its use has 
never led to medical problems and restriction of its use 
could result in the slowdown of medical progress. 
Sincerely yours 
Arnold L. Demain 
[ 573 ] 
