Syngenics, Inc 
March 25, 1981 
Dr. Elizabeth Milewskl 
Building 31, Room 4A42 
ORDA-NIH 
Bethesda, MD 20205 
Dear Dr. Milewski: 
I am writing to you in support of Dr. Donald H. Dean’s request for a 
reduction in the restriction Imposed by the present NIH Guidelines 
involving the use of subtilis for recombinant DNA research. 
Dr. Dean’s proposed changes are listed on page two of this communication. 
I think that it is time to examine the present Guideline restrictions in 
the light of all available data. When this is done, subtilis will be 
seen as a safe alternate host-vector system. 
Sincerely yours 
JJD/mpy 
2904 Corvin Drive • Santa Clara • California 95051 • (408) 730-0843 
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