McARDLE LABORATORY 
FOR CANCER RESEARCH 
DEPARTMENT OF ONCQLOOY 
MEDICAL SCHOOL, UNIVERSITY OF WISCONSIN 
April 14, 1981 
Dr. William Gartland 
Office of Recombinant DNA 
National Institute of General 
Medical Sciences 
Building 31, 4A52 
Bethesda, Maryland 20205 
Dear Bill: 
I would like to endorse strongly the proposal of Drs. A. Campbell and 
David Baltimore which would restore the true advisory nature of the NIH Guide- 
lines and eliminate their mandatory and regulatory provisions [Federal Register 
46 (1981) 17994-7]. There is very strong "grass-root" support for this pro- 
posal, which agrees with the present assessment that the hypothetical Inadvertent 
risks, specifically due to use of the recombinant DNA technique, are not signi- 
ficant from the practical point of view. Also, the present imposition of 
unnecessary regulations, which are known to have adverse effects [see TIBS, 
2 (1978) p. N243], is certainly not justified by these hypothetical risks. 
It was nice to see you again in Reston. 
Sincerely yours. 
V 
WS :mjg 
450 North Randall Avenue, Madison. Wisconsin 53706 
608-262-2177 
[ 578 ] 
