UNIVERSITY OF CALIFORNIA, SAN FRANCISCO 
BERKELEY • DAVIS • IRVINE • LOS ANGELES • RIVERSIDE • SAN DIEGO • SAN FRANCISCO 
SANTA BARBARA • SANTA CRUZ 
SCHOOL OF MEDICINE 
DEPARTMENT OF BIOCHEMISTRY AND BIOPHYSICS 
SAN FRANCISCO, CALIFORNIA 94143 
(41 S) 666-4324 
April 20, 1981 
Dr. William Gartland 
Office of Recombinant DNA 
National Institute of General Medical Sciences 
Building 31 
4A52 
Bethesda, Maryland 20203 
Dear Dr. Gartland: 
I would like to strongly recommend adoption of the proposal for 
changing the MIH Guidelines as published In the Federal Register of 
Friday, March 20, 1981 on pages 17994-7 (Vol. 46, #54). This proposal 
to convert the Guidelines Into a non-regulatory code makes complete 
sense In terms of the past years experiences in showing lack of 
risk and brings recombinant DNA research into the same framework as 
other microbiological research. 
Sincerely yours. 
Howard M. Goodman 
Professor of Biochemistry 
HMG:bm 
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