THE3 WISTAR INSTITUTE 
THIRTY- SIXTH STREET AT SPRUCE 
PHILADELPHIA, PA. 19104 
HILARY KOPROW8K1, M.D. 
Phonb: (215) 24S-S700 
DIRECTOR 
CABLE address: WI8TARIN8T 
December 23, 1981 
Director 
Office of Recombinant DNA Activities 
Building 31 , Room 4A52 
National Institutes of Health 
Bethesda, Maryland 20205 
Dear Sir: 
This letter is in response to the proposed revision of the NIH 
guidelines for research involving recombinant DNA. The members of our 
Institutional Biosafety Committee met to discuss the proposed revisions 
and we feel that we are in complete agreement with the spirit of these 
revisions. We feel, however, that it would be beneficial to include 
with these revisions a strong recommendation that each institution 
continue to have an internal review committee so that safety and 
responsibility in experimentation will be maintained. 
The Wistar Institute had an internal committee before the guidelines 
required that we do so and will continue this practice in the future. 
We hope that other responsible institutes do the same. 
Sincerely yours, 
Peter Curtis, Ph.D. 
Chairman, Institutional 
Biosafety Committee 
/sb 
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