UNIVERSITY OF VIRGINIA 
School op Medicine 
BOX 441 
CHARLOTTESVILLE, VIRGINIA XEBOB 
DKPARTMBNT OP MICROBIOLOeV 
January 4, 1982 
William J. Gartland, Jr., Ph.D., Director 
Office of Recombinant DNA Activities 
Building 31, Room 4A52 
National Institutes of Health 
Bethesda, Maryland 20205 
Dear Dr. Gartland: 
I would like to go on record as strongly favoring the proposed revision 
by the Recombinant DNA Advisory Committee published in the Federal Register 
dated December 4, 1981 to the effect that 
1. the Guidelines would cease to be mandatory, 
2. Section III of the Guidelines would be greatly simplified and most 
experiments be done under PI containment facilities, 
3. the prohibition section (I-D) be eliminated except for I-D-2 and 
I-D-5. 
This revision is long overdue and would greatly advance recombinant DNA 
technology without public risk. I congratulate you and the RAC and hope you 
proceed with these revisions forthwith. 
Sincerely yours, 
Robert R. Wagner, M.D. 
RRWrlrp Professor and Chairman 
[6301 
