Dr. William J. Gartland, Jr. 
Page 2 
more, If the gene Is cloned out of the normal pathogenic host 
Into a nonpathogenlc strain unable to colonize people, that 
should add further to the safety. Thus, 1 see no logic for singling 
out toxins for special treatment In the guidelines or for dividing 
toxin experiments Into classes dependent on LD5o> I therefore 
object to an "admonishment" against cloning of five particular 
toxin genes, (vhatever "admonishment" means). 
Sincerely yours 
[640] 
