McARDLE] LABORATORY 
FOR CANCER RESEARCH 
DEPARTMENT OF ONCOLOGY 
MEDICAL SCHOOL, UNIVERSITY OF WISCONSIN 
January 13, 1982 
To: William J. Gartland 
From: Howard M. Temin 
Subject: Proposed Revisions of NIH Guidelines for Research Involving 
Recombinant DNA Molecules 
Thank you for sending the Federal Registers of Dec. 4 and 7. 
Philosophically, I am most in sympathy with the proposed guidelines in 
the Dec. 4 Federal Register. Certainly, in hindsight, such guidelines are 
all that should have been present when recombinant DNA work was just beginning. 
However, now that we have had the history of the last years and the public 
concern about recombinant DNA, I question whether we can go back to essentially 
no regulation. I believe that we cannot and need some mechanism to protect in 
the future both the infant genetic engineering industry and academic work with 
recombinant DNA. 
Therefore, I support a revision like that of Dr. Gottesman described in the 
Dec. 7 Federal Register. However, I think that more experiments should not 
require prior IBC approval, for example, section III-B-3-d should be moved to 
III-C, etc. 
450 North Randall Avenue, Madison, Wisconsin 53706 
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