The Uhivotsity of %stem Cancer Gaiter 
M. D. Anderson Hoq>ital and Tumor Institute 
Tex» Medical Center • 67?3 Bertner Avenue • Houston, Texas 77030 
Office of the President 
January 29, 1982 
Director, Office of Recombinant 
DNA Activities 
Building 31, Room 4A52 
National Institutes of Health 
Bethesda, Maryland 20205 
Dear Sirs: 
The Subcommittee on Recombinant DNA of The University of Texas 
System Cancer Center has reviewed the two proposed Revised Guide- 
lines for Recombinant DNA Research in the Federal Registers of 
December 4 and December 7, 1981. While the subcommittee sees no 
prospects of accidents associated with recombinant DNA research, we 
consider it prudent and timely to support the proposed guidelines 
of December 7, 1981 submitted by Dr. Susan Gottesman. These guide- 
lines retain the Institutional Biosafety Committee to oversee 
certain experiments and NIH compliance required for others. We 
support a requirement for notification to the IBC of certain other 
recombinant DNA experiments as outlined in the Gottesman proposal. 
Sincerely, 
HDH:bb 
1738 ] 
