PREFACE 
This is the sixteenth in a series constituting a "public record" of activities in regard to the 
National Institutes of Health (NIH) Guidelines for recombinant DNA research. 
The first fifteen volumes cover events from February 1975 through June 1992. This 
sixteenth volume covers events from July 1992 through December 1992. 
Starting from Volume 14, human gene transfer/therapy protocols that have been approved 
by the NIH Recombinant DNA Advisory Committee, are collected. Documents of each 
human study include the clinical protocol, the Informed Consent document describing the 
study in a nontechnical language, both scientific and nontechnical abstracts, and curriculum 
vitae of the principal investigators. 
Volumes 1 through 5 in this series and the Environmental Impact Statement may be 
purchased from the Superintendent of Documents, U.S. Government Printing Office (GPO), 
Washington, DC 20402 or GPO bookstores in selected cities throughout the United States. 
They may also be viewed in some 600 public libraries of the GPO depository system. The 
GPO stock numbers are: Volume 1, 017-004-00398-6; Volume 2, 017-040-00422-2; Volume 
2 Supplement (Environmental Impact Statement), 017-040-00413-3; Volume 3, 017-040- 
00429-0; Volume 3 Appendices, 017-040-0043-3; Volume 4, 017-040-00443-5; Volume 4 
Appendices 017-040-00422-7; and Volume 5, 017-040-00470-2. Volumes 6 through 16 are 
available from the Office of Recombinant DNA Activities, Building 31, Room 4B11, 
National Institutes of Health, Bethesda, MD 20892 USA. 
Recombinant DNA Research, Volume 16 
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