MEDICAL RECORD 
CONTINUATION SHEET for either: 
NIH 2514-1, Consent to Participate In A Clinical Research Study 
NIH 2514-2, Minor Patient’s Assent to Participate In A Clinical Research Study 
S T UDY NUMBER: 
CONTINUATION: page_i_of J£ pages. 
nausea and vomiting, diarrhea, bleeding and inf lamination of 
the bladder and rarely heart or lung damage. MESNA is a 
compound that protects the bladder from cyclophosphamide? it 
has no serious side effects. 
G-CSF may cause bone pain, muscle aches, and itching and 
redness at the injection site. It may also cause fluid 
retention and a temporary drop in your platelet count. Very 
rarely it can cause more serious allergic reactions. 
Collecting "stem cells" from the circulating blood as compared 
to the bone marrow may have two advantages: 1) the blood cells 
may speed recovery of white blood cells and platelets after 
the transplant, and 2) the blood cells may be less 
contaminated with tumor cells than the bone marrow. Your blood 
counts will become very low soon after the cyclophosphamide 
infusion, but will recover within 7-10 days. Just as the 
blood counts start to recover, we will begin to collect the 
"stem cells" from your blood, because that is when the largest 
number of them circulate. 
To obtain these cells, you will be hooked up by your 
intravenous line to an apheresis machine in the Blood Bank. 
This machine will take blood that is flowing out of your vein 
and separate out the peripheral blood stem cells, then return 
the rest of the bloody to you through your vein. The blood 
stem cells will then be frozen and stored. Each pheresis 
procedure takes several hours and you may need as many as ten 
procedures over 10-14 days. The risks of apheresis are low. 
You may feel light-headed and have tingling around your mouth, 
fingers and toes as a side effect of the blood thinnner used 
in the machine. 
You will be in the Clinical Center for approximately two-three 
weeks for the cyclophosphamide and G-CSF treatments and the 
apheresis collections. Once your blood counts start to 
recover, you may complete the apheresis collections as an 
outpatient. When the collections are completed, the G-CSF will 
be stopped, and you will either go home to rest for several 
weeks, or remain in the Clinical Center awaiting the next 
phase of the protocol. 
4) 5-Fluorouracil Treatment and Bone Harrow Harvest: At least 
two weeks after the completion of the pheresis procedures, you 
will have a bone marrow aspirate and biopsy to make sure your 
PATIENT IDENTIFICATION 
CONTINUATION SHEET for either: 
NIH-2S1 4-1 (10-84) 
Recombinant DNA Research, Volume 16 
[73] 
