6.4 After bone marrow recovery from induction chemotherapy has 
occurred (ANC > 2000/llI and platelets >1 00.000/un. patients 
will undergo bone marrow harvest (see Section 5.1) . At least 
two weeks will elapse from recovery of the blood counts after 
induction therapy and bone marrow harvest. 
6.5 ICE Chemotherapy-Regimen: 
Drugs: Days 1 
Ifosfamide x 
4 g/M2/day I.V. q.d. 
days 1 to 4 (4 days) 
CBDCA x 
600 mg/M2/day CIV 
days 1 to 4 (72 hours) 
Etoposide xx 
250 mg/M2/q12 hrs I.V. 
on days 1 to 3 (6 doses) 
Mesna x 
6400 mg/M2/day I.V. 
on days 1 to 4 (4 days) 
As outlined below: 
Mesna loading dose: 800 mg/M2 I.V. with Ifosfamide (hr 2-4) 
Constant infusion: 800 mg/M2 I.V. over 3 hr (hr 4-7) 
Bolus doses: 800 mg/M2/dose I.V. q 3 hr x 6 doses 
(hr 7, 10, ...) 
Bone Marrow Reinfusion Day 7 X 
Day 8: Beginning G-CSF lOjig/kg SC daily until AGC 
>2000/}il on 3 successive determinations. 
Bactrim DS 1 tab PO BID of Mon., Tues., and Wed. upon 
admission and for 3 months post-discharge. 
Z 3. 4 5. £ Z 
XXX 
XXXXXXXXX X 
XX XX 
XXX 
Recombinant DNA Research, Volume 16 
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