Clotrimazole Troche 10 mg SUCK q 4th while awake beginning 
Day 1 continuing until wbc recovery. 
6.6 After ICE chemotherapy on days 1-4, patients will undergo 
bone marrow reinfusion on Day 7. The bone marrow to be 
reinfused will consist of the CD34+ stem cells that have been 
transduced with a retroviral vector bearing the neomycin • 
resistance marker gene ( neo) as well as the 70% of the bone 
marrow harvest that was cryopreserved. 
6.7 Beginning on Day 8 patients will be treated with G-CSF 
lOjig/Kg SC daily until the ANC >2000/pl on three successive 
determinations. 
6.8 Patients will be monitored with daily CBC, platelet count, 
differential, and chemistry profiles. 
6.9 Therapy Instructions : 
6.9.1 General Instructions: All blood products must be 
irradiated and a double luman Hickman catheter must be 
in place. On admission and for 3 months following 
discharge, patients must take Bactrim DS 1 po BID Q 
Monday/Tuesday/Wednesday. MOUTH CARE: Peridex 
mouthwash 30 cc po swish and spit Q8h; NaH 2 C 03 Rinse 
(2 tablespoon/500 cc sterile H 2 O) 30 cc po swish and 
spit Q4th; Clotrimazole Troche 10 mg such A4th and if 
not tolerated, Nystatin 20 cc po swish and swallow Q4th. 
ANTI-EMETIC REGiMEN (suggested): Ondansetron 0.15 
mg/Kg IV Q4 or Q6 hours; Ativan 1-2 mg l>V> Q8-12. Do 
not over-sedate patients and DO NOT GIVE STEROIDS. 
Droperidol and diphenhydramine are recommended for 
breakthrough N & V. 
6.9.2 ICE Administration: Hydration will start 24 hour prior to 
ICE and will be D5NS at 300 ml/hr on day 0 and repeat 
creatinine clearance obtained. Chemotherapy should 
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Recombinant DNA Research, Volume 16 
