CLINICAL RESEARCH PROJECT 
Date 
Project # qs-H-fz, 
Drug/ Device # 
IND/IDE # 
IND/IDE Holder: 
Burrouahs-Wel lcome 
To: Joel Moss, M.D., Acting Chair, ICRS, NHLBI 
Recommended by : 
Harry Keiser, M.D., Clinical Director, NHLBI 
Title : High-Dose Cyclophosphamide and Total Body Irradiation 
with Autologous Bone Marrow and Peripheral Blood Stem 
Cell Support Followed by Interferon For Treatment of 
Chronic Myelogenous Leukemia 
Other Identifying Words : 
granulocyte colony stimulating factor, cyclophosphamide, 
5-f luorouracil , bone marrow transplantation, stem cell, 
apheresis 
Principal Investigator : 
Cynthia E. Dunbar, M.D., Senior Clinical Investigator, 
CHB , NHLBI ^ 
Medically Responsible Investigator : 
Cynthia E. Dunbar, M.D., Senior Clinical Investigator, 
CHB , NHLBI 
Associate Investigators : . 
Arthur W. Nienhui^s, M.D., Chief, CHB, NHLBI 
F. Marc Stewart, M.D. University of Virginia School of 
Medicine, Charlottesville, VA P/l yS Q . 
Neal S. Young, M.D., Section Chief, CHB, 'NHLBI 
Michele Cottier-Fox, M.D. , Department of Transfusion 
Medicine, Clinical Center 
Frank Sullivan, M.D., Radiation Oncology Branch, NCI'-fo 
Susan Leitman, M.D., Department of Transfusion Medicine, 
Clinical Center 
Estimated Duration of Study: 3 years 
Subjects of Study: Number Sex Ace Range 
Patients 24 either < 65 
Project Uses ionizing radiation? Yes 
Radiation use is medically indicated 
Project involves use of Durable Power of Att^r 
Multi-Institutional Project? Yes 
Collaborating Institute Clinical Director 
Dr. Gregory Curt, Clinical Director, NCI 
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Recombinant DNA Research, Volume 16 
