-6 or earlier: Bone marrow harvest. 
-6 Begin pentoxifylline 1600 mg/day po divided q6 
hrs . 
-6 Begin allopurinol 300 mg po qd and iv fluid 
hydration at 100-150 cc/hr. Supplemental potassium 
and magnesium may be added as necessary, and 
bicarbonate infusion may be given in the rare . 
patient at high risk for tumor lysis syndrome. 
-5 Begin bladder irrigation 500cc irrigant/h prior to 
cyclophosphamide; Mesna 24 mg/kg I.V. over 30 
minutes at 0, 3, 6, and 9 hours post- 
cyclophosphamide . 
cyclophosphamide 60 mg/kg I.V. (see 11.2 for dose 
modif icat ions ) 
-4 cyclophosphamide 60 mg/kg I.V. 
Mesna 24 mg/kg I.V. over 30 minutes at 0, 3, 6, 
and 9 hours post-cyclophosphamide. 
-3 200 cGy total body irradiation X 2. Dose rate 
lOcGy/minute. (See appendix C for further 
information) 
-2 200 cGy total body irradiation X 2 
-1 200 cGy total body irradiation X 2 
-1 stop allopurinol 
0 Autologous marrow and peripheral blood stem cell 
reinfusion 
Three hours after stem cell infusion begin 
granulocyte-macrophage colony-stimulating factor 
(G-CSF) 12 ug/kg/day IV over 2 hours, continue 
until absolute neutrophil count reaches 1000/mm 3 
for three consecutive days, or day 28. May 
restart G-CSF if ANC falls below 500/mm 3 . See 
appendix for detailed drug information. 
5.5 Marrow/PBSC Infusion 
Premedicate patients with benadryl 25 mg IVP and 
hydrocortisone 100 mg IVP. Cells are infused 
intravenously at the bedside over 30-120 minutes 
without a filter after rapid thawing in a 37 degree 
water bath. Total, volume expected to be 100-500 cc. 
Toxicities include the following: 
Recombinant DNA Research, Volume 16 
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