2. Patients will receive pooled random donor 
platelets or single donor apheresis platelets 
(equivalent to 8-12 random donor platelets) . In 
patients who fail to demonstrate and adequate 
increment in counts and is symptomatic from 
thrombocytopenia, more elaborate methods of 
platelet selection (HLA matched, cross matched) 
will be attempted. 
3. Irradiation: All blood products are irradiated 
with 2000 cGy prior to infusion to inactivate the 
lymphocytes. Irradiation of products begins 
routinely in patients who begin cytoreductive 
treatment and continues indefinitely. 
4. Leukocyte poor platelets (filtered) will be used 
for all platelet transfusions. 
6.3 Red cell transfusions 
1. Indications: Hct should be kept above 30 with 
packed cell preparations. 
2. Irradiation: All blood products are irradiated 
with a minimum of 2000 cGy prior to infusion to 
inactivate lymphocytes. Irradiation of products 
begins routinely in patients who begin 
cytoreductive treatment and continues 
indefinitely. 
3. Leukocyte poor red cells (filtered) are given to 
all transplant patients 
6.4 Total parenteral nutrition 
Indications: All patients require total parenteral 
nutrition instituted at the first sign of inadequate 
oral intake. Nutritionist will follow patients and 
advise accordingly. 
6.5 Treatment of Infections 
1. For treatment of fever greater than 38.3°C and an 
absolute granulocyte count less than 1000/mm 3 , the 
institution of broad spectrum empiric antibiotic 
coverage is necessary preferably with an anti- 
pseudomonas penicillin/antipseudomonal beta-lactam 
and aminoglycoside or monotherapy with ceftazadime 
alone. If a skin source is suspected, vancomycin 
will be added. If FUO fails to resolve in three- 
four days, consideration will be given for the 
empiric addition of amphotericin-B . 
Recombinant DNA Research, Volume 16 
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