MEDICAL RECORD 
CONTINUATION SHEET for either: 
STUDY NUMBER: 
NIH 2514-1, Consent to Participate In A Clinical Research Study 
NIH 2514-2, Minor Patient’s Assent to Participate In A Clinical Research Study 
CONTINUATION: page 3 nf 14 
Bone Marrow Harvest may cause pain where the needles are 
inserted, nerve damage where the needles are inserted, 
bruising, slight bleeding, and a small risk of infection. 
Anesthesia may cause minor discomforts such as nausea, 
vomiting, sore throat, or cuts and bruises to the mouth. 
Major illnesses are possible and include pneumonia, heart 
attack, or blood clots in the lungs or other organs. 
7) Patients in Group 1 will proceed to Transplantation 
preferably, but not exclusively within the first 12 months 
following bone marrow and peripheral blood stem cell 
harvest. Very high dose chemotherapy and radiation will be 
given to try and destroy all leukemic cells remaining in 
your body. Because your entire bone marrow will be 
destroyed in this process, you will need to be given back 
' the previously collected marrow and peripheral blood stem 
cells as a "rescue" from the effects of the treatment. 
If your central venous catheter has been removed you will 
have another one placed approximately 2-3 weeks prior to 
your transplant. Increases of uric acid in the blood and 
urine can result from the destruction of blood cells by the 
chemotherapy and radiation and can damage the kidneys. 
Starting on 6 days before the transplant you will receive 
allopurinol 300mg by mouth and intravenous fluids with - 
sodium bicarbonate to help prevent elevated uric acid 
levels. A catheter will be placed in your bladder to allow 
continuous rinsing of the bladder with salt water before 
chemotherapy begins. This irrigation is done to wash out 
the chemotherapy drug cyclophosphamide which can irritate 
the bladder. If you have had a prior herpes virus infection 
you will also begin the antiviral drug acyclovir. You will 
be given two daily intravenous doses of cyclophosphamide the 
fifth and the fourth day before transplant. You will also be 
given an infusion of a drug called MESNA that protects your 
bladder from the damaging effects of cyclophosphamide. 24 
hours later the catheter will be removed from your bladder. 
You will receive a total of 1200 rads of irradiation over 
three days (200 rads twice a day the third to the final day 
before transplant) . On the day of the transplant your 
harvested bone marrow and peripheral blood will be thawed 
and infused through your central venous catheter. 
PATIENT IDENTIFICATION 
CONTINUATION SHEET for either: 
pages. 
Recombinant DNA Research, Volume 16 
[187] 
