Recombinant DNA Advisoiy Committee - 09/14-15/92 
I. CALL TO ORDER 
Dr. Murray (Chair) called the meeting to order. She noted that the notice of meeting 
was published in the Federal Register 15 days prior to September 14 as required by the 
National Institutes of Health Guidelines for Research Involving Recombinant DNA 
Molecules (NIH Guidelines). The RAC serves as advisor to the NIH Director. The 
Director may accept, reject, or send the RAC's recommendations back to the committee 
for further deliberation. 
Dr. Murray stated that a quorum was present and outlined the order in which speakers 
would be recognized. The primary and secondary reviewers will present their reviews of 
the protocol, followed by responses from the principal investigators of the protocols. 
The Chair will then recognize other RAC members, ad hoc consultants, other NIH and 
Federal employees, the public who have submitted written statements prior to the 
meeting, followed by the public at large. She welcomed Dr. Gary Chase of Johns 
Hopkins University as a new member of the RAC. She noted that a quorum was 
present. 
II. MINUTES OF THE JUNE 1-2, 1992, MEETING 
Dr. Murray called on Dr. Parkman to review the minutes of the June 1 and 2, 1992, 
RAC meeting. Dr. Parkman stated that the minutes of the June 1-2, 1992, RAC meeting 
were an accurate reflection of the committee's deliberations; however, he suggested 
several minor corrections. Drs. D. Miller and Geiduschek stated that they had additional 
minor corrections, and that they would submit these changes in writing. 
A motion was made by Dr. Parkman and seconded by Dr. DeLeon to approve the 
minutes including the changes submitted by Drs. Parkman, D. Miller, and Geiduschek. 
Dr. Murray called for the vote. The minutes were approved by a vote of 17 in favor, 0 
opposed, and no abstentions. 
III. PROPOSED ADDITION TO APPENDIX D OF THE NIH GUIDELINES REGARDING 
A HUMAN GENE TRANSFER PROTOCOL ENTITLED: A STUDY OF THE SAFETY 
AND SURVIVAL OF THE ADOPTIVE TRANSFER OF GENETICALLY MARKED 
SYNGENEIC LYMPHOCYTES IN HIV INFECTED IDENTICAL TWINS /DRS. 
WALKER AND BLAESE 
Review--Dr. Post 
Dr. Murray called on Dr. Post to present his primary review of the protocol submitted by 
Drs. Robert Walker and R. Michael Blaese of the NIH, Bethesda, Maryland. Dr. Post 
provided a brief overview of the protocol. The protocol involves the in vitro culture of 
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