positive local site culture. 
f) Urinary tract infection will be defined as a urine culture 
with ^ 50,000 colonies of a single organism with or 
without symptoms. 
f. All definitions above involve the presence of a positive culture as essential 
for the definition of infection. Tissue histology may be used in instances 
where the culture is negative for the following: 
1) Any positive FA for Legionella or herpes viruses (or other 
organism-specific monoclonal antibody) 
2) Any septate or non-septate hyphal elements 
3) Pneumocystis 
P 
g. Recurrent Infection 
Recurrent infection will be defined as infection which is documented >7 
days after the discontinuation of appropriate antibiotics. 
2. Time for platelet count to >50,000 cells/mm 3 . 
3. Number of platelet and red cell transfusions. 
4. The number of days receiving antibiotics and the number of febrile days. 
5. Bilirubin and creatinine levels. 
6. Days of hospital stay. 
7. Clinical course of recovery after hospital discharge. 
8. Mortality. 
Outline of Evaluation and Treatment 
A. Patient Evaluation 
1. History. 
2. Physical. 
3. Autologous bone marrow harvest and storage with samples for Dr.’s Bensinger 
and Torok-Storb. 
4. Hematologic assays: CBC; differential; preplatelet count; and reticulocyte count 
5. Cultures: blood, stool, urine, and throat for pathogenic bacteria, viruses and 
fungi. 
6. FH1 (electrolytes, glucose, BUN, creatinine) F II (Calcium, phosphorus, albumin, 
magnesium), F III (bilirubin, alkaline phosphatase, liver enzymes) 
7. Viral infection status: HIV, HSsAg and antibody titers for cytomegalovirus 
(CMV) and toxoplasmosis. 
8. Chest x-ray. 
9. EKG. 
B. Prior to Transplantation 
1. Administration of G-CSF with daily laboratories. 
2. Peripheral blood collection and storage. 
Recombinant DNA Research, Volume 16 
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