THE FRED HUTCHINSON CANCER RESEARCH CENTER 
AND THE UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE 
DEPARTMENT OF MEDICINE, DIVISION OF ONCOLOGY 
1. Consent to Participate in A Trial of G-CSF Stimulated Peripheral Blood Stem Cells for 
Engraftment in Identical Twins - Donor 
INVESTIGATORS: C.D. Buckner, M.D., Professor of Medicine, UW, Member, FHCRC (667-4453) W. 
Bensinger, M.D. Associate Professor of Medicine, UW, Associate Member, FHCRC, (667-4933); F. 
Schuening, M.D., Assistant Member, FHCRC (667-4410); J. Singer, M.D.; R. Storb, M.D., Professor of 
Medicine, UW, Member, FHCRC, (667-4407); S. Rowley, M.D., Associate Member, FHCRC, (667- 
5914); P. Martin, M.D., Professor of Medicine, UW, Member, FHCRC, (667-4798); L. Fisher, PhD., 
Professor of Biostatistics, UW, Member, FHCRC, (667-4567). 
Emergency (24 hour) Phone: 667-5001 
Attending physician: Phone: 
BACKGROUND 
Your identical twin is about to begin treatment with intensive chemotherapy and radiation treatments in 
an attempt to eradicate the cancer. This intensive treatment would not be possible without the use of 
stem cells (cells that are found in the bone marrow that allow blood counts to recover) to replace cells 
that are damaged by the intensive treatment. The usual source of these stem cells is from bone marrow 
given by the donor. This procedure requires a brief hospitalization and a harvest of the marrow in an 
operating room usually while the donor is asleep. Recently, it has been learned that it is possible to 
stimulate these stem cells to circulate in the blood by using a growth factor (a substance that stimulates 
blood cells). This growth factor, called G-CSF, will allow us to collect enough stem cells from your 
peripheral blood to give to your identical twin instead of marrow for the recovery of bone marrow 
function. Studies involving patients own stem cells (autologous) show that stem cells collected from the 
peripheral blood in this manner result in a more rapid recovery of blood counts than marrow alone. By 
participating in this study, you may be able to avoid an operation requiring marrow harvest anesthesia 
and the overnight stay in the hospital. 
PURPOSE 
The purpose of this study it to test whether growth factor stimulated peripheral blood stem cells can 
serve as a substitute for bone marrow cells in patients undergoing transplant from identical twins. 
There is no guarantee or promise that this procedure will be successful. 
PROCEDURES 
This treatment will require that you have subcutaneous injection with the growth factor G-CSF every 
day for five days. The injection(s) will be given in your thighs or upper arms. 
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