the cancer cells. This treatment will be repeated monthly as long as there is evidence 
that the tumor is not growing. The cost of the routine bronchoscopy and biopsies 
which are part of the work up of patient’s condition shall be his/her responsibility. 
RISKS, SIDE EFFECTS AND DISCOMFORTS TO PARTICIPANTS: 
A few additional biopsies will be required. A bronchoscopic biopsy samples a very 
tiny piece of the mucosa. Risks of biopsies include hemoptysis (coughing up blood) 
which is usually transient and self limited. Severe hemorrhage requiring emergency 
maneuvers including intubation and thoracotomy are exceedingly rare. Although 
extremely rare, any experimental procedure may result in unforeseen risks. 
Appropriate medical therapy will be made available for the treatment of such side 
effects. 
4a. This clinical procedure may involve unforeseeable risks to the participant (or to 
the embryo or fetus, if the participant is or may become pregnant during 
treatment). To help prevent injury to unborn children, upon recommendation by 
the attending physician, the participants should practice adequate methods of 
birth control throughout the period of their involvement in this clinical research 
study. 
4b. Possibility of Causing a New Cancer. The possibility of causing cancer in 
normal cells exists although this risk is thought to be very low. Tests of viral 
supernate will be conducted to assure that possible disease causing virus is not 
present in the material to be injected. 
Risk from murine retrovirus. The retrovirus derived from the Moloney murine 
leukemia virus is modified so that it no longer contains intact viral genes. Thus it 
cannot produce an intact infectious virus. Therefore, the risk of getting a virus 
infection is extremely low. 
4c. A small amount of protamine is added to the retroviral mixture. Infrequent 
allergic reactions and low blood pressure have occurred as side-effects when 
this drug is given. These are very unlikely to occur with the small dose given. 
POTENTIAL BENEFITS: There is potential therapeutic benefit from this procedure. It is 
possible that injection of the retrovirus will slow the growth of the tumor and prevent 
further blockage of the lung. This study will also form the basis for future studies 
which may be able to apply this technology to the treatment of earlier cancer. 
ALTERNATE PROCEDURES OR TREATMENTS: Patients will be eligible for this study 
if conventional therapy such as surgery or external beam radiation therapy has 
already been performed or cannot be done. 
PERMISSION FOR AUTOPSY: It is anticipated that permission to perform an autopsy 
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