hre-LUt remission: Clinical Protocol 
Neuroblastoma Bone Marrow Purging System 
BAXTER HEALTHCARE CORPORATION, HYLAND DIVISION 
Table 6.2-1: Relationship between the number of neuroblastoma progenitor cells giving 
rise to a relapse and the probability of detecting marked tumor cells in the relapse. 
TExMT = 0.005 
NC - # of Cells Producing Relapse 
Pa = Probability of relapse containing marked cells 
1 
0.005 
5 
0.025 
10 
0.049 
100 
0394 
1000 
0.993 
3000 
1.000 
Table 6.2-1 shows that if the relapse in a patient arises from a single progenitor cell, then 
the probability that the relapse contains a marked cell is 0.005. Likewise, if 10 
progenitor cells are involved, then the probability that the relapse contains marked cells 
is .049. 
If a cohort of N patients with an assumed relapse rate of pr, has the same number of 
progenitor cells (NC) giving rise to the relapse, then the probability of detecting at least 
one marked relapse is given by: 
P = 1 - (1 - prpm) n 
Values of p for a range of values of NC and N with pr = 0.6 and TE x MT = 0.005 
are shown in Table 6.2-2. Also given is the expected number of marked relapses in the 
samples of size N. An important assumption is that NC is the same for all patients. 
There are no data available on the number of progenitor cells involved in neuroblastoma 
[474] 
Recombinant DNA Research, Volume 16 
