TABLE OF CONTENTS 
1. INTRODUCTION AND BACKGROUND 3 
2. OBJECTIVES 5 
3. EXPERIMENTAL DESIGN 5 
4. PROTOCOL SCHEMA 9 
5. PATIENT SELECTION 10 
6. LOCATION 11 
7. PATIENT EVALUATION 11 
8. CRITERIA FOR RESPONSE 12 
9. REPORTING OF ADVERSE REACTIONS 12 
10. POTENTIAL RISKS OF RETROVIRAL- MEDIATED GENE TRANSFER 13 
11. STATISTICAL CONSIDERATIONS 15 
12. ETHICAL CONSIDERATIONS 15 
13. RESPONSIBILITIES 15 
14. RISKS AND BENEFITS • 15 
15. COST AND PAYMENTS 16 
16. TREATMENT SCHEMA 16 
17 . REFERENCES 17 
18. CONSENT 19 
19. APPENDIX 23 
20. SUMMARY 28 
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Recombinant DNA Research, Volume 16 
