17.0 REFERENCES 
1. Rosenberg SA , et al , 1989. Experience with the use of high-dose 
interleukin- 2 in the treatment of 652 cancer patients. Ann Surg 210:474- 
484 . 
2. Rubin JT and Lotze MT. 1992. Adoptive immunotherapy of cancer, in The 
biological approach to cancer treatment: biomodulation . MS Mitchell, ed. 
McGraw-Hill, (in press). 
3. Ksander BR, et al. 1992. Studies on the role of local helper cell signals 
in rejection of intraocular tumors by cytotoxic T cells. J Immunol. 
( submitted) . 
4. Bosco M, et al. 1990. Low doses of IL-4 injected perilymphatically in 
tumor-bearing mice inhibit the growth of poorly and apparently 
nonimmunogenic tumors and induce a tumor-specific immune memory. J Immunol 
145:3136-3143. 
5. Tepper RI , e_t al. 1989. Murine interleukin-4 displays potent anti- tumor 
activity in vivo. Cell 57:503-512. 
6. Golumbek PT , et al. 1991. Treatment of established renal cancer by tumor 
cells engineered to secrete interleukin-4. Science 254:713-716. 
7. Masinovsky B, et al. 1990. IL-4 acts synergistically with IL-l-beta to 
promote lymphocyte adhesion to microvascular endothelium by induction of 
vascular cell adhesion molecule-1. J Immunol 145:2886-2895. 
8. Stuart PM, et al. 1988. Induction of class I and class II MHC antigen 
expression on bone marrow- derived macrophages by IL-4. J Immunol. 140:1452- 
1457. 
9. Aiello FB, et al. 1990. A role for cytokines in antigen presentation: IL-1 
and IL-4 induce accessory functions of antigen presenting cells. J Immunol 
144:2572-2581. 
10. Mitchell LC , et al. 1989. Promotion of human T lymphocyte proliferation by 
IL-4. J Immunol. 142:1548-1552. 
11. Kawakami Y, ej: al. 1989. IL-4 regulates IL-2 induction of lymphokine- 
activated killer activity from human lymphocytes. J Immunol 142:3452-3461. 
12. Rosenberg SA, et al. 1990. Gene transfer into humans: immunotherapy of 
patients with advanced melanoma using tumor infiltrating lymphocytes 
modified by retroviral gene transduction. N Engl J Med 323:570-578. 
13. Dowling RD, e£ al. 1992. Thoracoscopic resection of pulmonary metastases. 
Chest (in press) . 
14. Miller AD and Rosman G. 1989. Improved retroviral vectors for gene transfer 
and expression. BioTechniques . 7:980-990. 
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