bMv^iwiiivMi. or\c i v^n 
Give Ibe following information tor the Key personnel «n<j con*ult*nti luted on page 2 Begin with the Principal 
Investigaior/Program Director Photocopy thu page tor each person 
NAME 
Michael T. Lotze, M.D. 
POSITION title Assoc. Dir. Pgh|BlRTHDATE (Mo. Day. Yr) 
Cancer Inst., Prof, of Surgery 7/11/52 
Molecular Genet ics A Blnrhpmt ry 
institution and LOCATION 
vwtduyn. jutn #5 n 
1 
DEGREE 1 
urging, j no mciUi 
YEAR 
CONFERRED 
re postdoctoral training / 
• 
FIELD OF STUDY 
Northwestern University Honors Program in 
Medical Education, Evanston, IL. 
Northwestern Medical School, Chicago, IL 
1 
1 
B. Med. Sci, 
M.D. 
1973 
1974, 
Premedical Studies 
Medicine 
RESEARCH AND PROFESSIONAL EXPERIENCE Concluding with present position, list, in chronological order, previous employment experience 
and honors include present membership on any Federal Government public advisory committee List, m chronological order, the titles and con- 
piete references to all publications dunng the past three years and to representative earlier publications pertinent to this application DO NO’ 
EXCEED TWO PAGES 
1975 Jr. Medical Fellow in Surgery, M.D. Anderson Tumor Institute, Houston, TX 
1975- 1976 lotern/Resideot in Surgery (1st Post Graduate Year) Strong Memorial Hospital, Rochester, NY 
1976- 1977 Assistant Resident in Surgery, Strong Memorial Hospital, Rochester, NY 
1977- 1978 Medical Officer, National Health Service Corps, Onamia, Minnesota 
1978- 1981 Staff Fellow, Surgery Branch, National Cancer Institute, Betbesda, Maryland 
1981- 1982 Sr. and Chief Res. in Surgery, University of Rochester, Rochester, New York 
1982- 1990 Senior Investigator, Surgery Branch, NCI, Betbesda, MD 
1990-Pres Chief, Section of Surgical Oncology, Dept, of Surgery and Assoc. Director, Pittsburgh Cancer 
Institute, University of Pittsburgh, PA 
Honors 
1982 Robert H. White Award for Excellence in Teaching, University of Rochester 
1986 4th Annual Edith Hamilton Cancer Lecturer, Cancer Center, Rochester, NY 
1987 Special Achievement Award; Department of Health and Human Services, NTH 
1988 4th Vender Lecturer, Evanston Hospital, Evanston, IL 
1990 Coorganizer UCLA Symposium on Cellular Immunity and the Immunotherapy of Cancer 
1990 14th Annual Lecturer, Internal Medicine Group, New Orleans, LA 
1990 Distinguished Lecturer, Virginia Mason Institute, Seattle, WA 
1991 Annual John Palmer Lecturer, University of Toronto, Toronto, Ontario 
1991 Tenth Hinshaw Lecturer, University of Rochester, Rochester, New York 
1992 Coorganizer Keystone Symposium on Melanoma and Biology of the Neural Crest, Taos, NM 
Selected Publications (out of 152) 
Lotze, M.T., Strausser, J.L, Rosenberg, SA.: ]n vitro growth of cytotoxic human lymphocytes. II. Use of T cell 
growth factor (TCGF) to done human T cells. J. Immunol. 124:2972-2978, 1980. 
Lotze, M.T., Mathlsen, DJ n Rosenberg, SA et aL The in vivo distribution of cultured autologous human and 
murine lymphoid cells grown in T cell growth factor (TCGF): Implications for the adoptive immunotherapy of 
tumors. J. Immunol . 125:2972-2978, 1980. 
Lotze, M.T., Grimm, EA-, Rosenberg, SA. et ml: Lysis of fresh and cultured autologous tumor by lymphocytes 
cultured in T cell growth factor (TCGF). Cancer Res. 41:4420-4425, 1981. 
Lotze, M.T., Frana, LW n Rosenberg, SA. et al: in vivo administration of purified human interleukin-2 I. Half 
life and immunologic effects of the Jurkat cell line derived IL-2. J. Immunol . 134:157-166, 1985. 
Lotze, M.T., Matory, Y.L, Rosenberg, SA. et al: In vivo administration of purified human interleukin-2. II. 
Half life, immunologic effects and expansion of peripheral lymphoid cells ig vivo with recombinant IL-2. JL 
Immunol . 135:2865-2875, 1985. 
Lotze, M.T., Custer, M.C., Rosenberg, SA. et al: Ig vivo administration of purified human ioterleukin-2. III. 
Development of Tac positive cells and circulating soluble IU2 receptors following 11^2 administration to humans. 
Cancer Res . 47:2188-2195, 1987. 
FF 
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Recombinant DNA Research, Volume 16 
