DUPLICATE COPY - USE IF NEEDED 
FJ* PRINCIPAL INVESTIGATOR/PROGRAM DIRECTOR 
BIOGRAPHICAL SKETCH 
Give the following Information for the Key pereonnet and consultant* listed on peg* 2 Begin with the Principe) 
Investigator/Program Director. Photocopy this page for each person. 
NAME 
POSITION TITLE 
BIRTH DATE (Mo.. Day. Yrj 
Joshua T. Rubin, M.D. 
Assistant Professor of 
Surgery 
8/3/52 
EDUCATION ( Begirt with baccalaureate or other Initial professional education, such as nu/?<ng, and inciuda postdoctoral training) 
INSTITUTION AND LOCATION 
OEGREE 
YEAR 
CONFERRED 
FIELD OF STUDY 
University of Virginia, 
Charlottesville , 
B.A. 
1974 
Pre-Med 
VA 
George Washington Univ, 
Washington, D.C. 
M.D. 
1979 
Medicine 
RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment, experience, 
and honors. Include present membership on any Federal Government public advisory committee List, in chronological order, the titles and com- 
plete references to all publications during the past three years and to representative easier publications pertinent to this application DO NOT 
EXCEED TWO PAGES. 
1979-1984 Intern and resident in surgery, Beth Israel Hospital, Boston, MA. 
1984-1985 Fellow in general surgery, Mount Sinai Hospital, Hartford, CT. 
1986-1990 Fellow in oncologic surgery, National Cancer Institute, Bethesda.MD. 
1990-pres. Assistant Professor of Surgery, University of Pittsburgh, Pgh. PA. 
Honors : B.A. cum laude, Alpha Omega Alpha 
Selected Bibliography: 
Rosenberg SA, Lotze MT, Muul LM, et al. A progress report on the treatment of 157 
patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or 
high dose interleukin-2 alone. N. Engl J Med. 1987; 316:889. 
Saris SC, Rosenberg SA, Friedman RB, et al. Penetration of recombinant interleukin 2 
across the blood-cerbrospinal fluid barrier. J Neurosurg 1988: 69:29. 
Saris SC, Patronas N, Rosenberg SA, et al. The effect of intravenous interleukin-2 on 
brain water content. J Neurosurg. 1989: 71:169. 
Rubin JT, Elwood LJ, Rosenberg SA, Lotze MT. Immunohistochemical correlates of 
response to recombinant interleukin-2 based immunotherapy in humans. Cancer Res 
1989. 49: 7086. 
Lotze MT, Jablons DJ, Rubin JT, et al. Cytokine therapy of patients with cancer. In: Prog 
Immunol, volume 7. Heidelberg-Springer Verlag, 1989. 
L 
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