Serum anti-adenovirus antibody titer 
Figure 4. 5 -A 
SERUM ANTI-ADENOVIRUS ANTIBODIES ASSOCIATED WITH 
RESPIRATORY TRACT ADMINISTRATION OF ADENOVIRUS VECTORS 
(Cotton Rats) 
2,621,440 
- □ Untreated 
655,360 
O Vehicle day 0, vehicle day 7 
a Ad-cftr day 0 
163,840 
_ • Ad-cftr day 0, vehicle day 7 
• 
A 
•• 
40,960 
- 
A 
— 
AAA 
• 
10,240 
AA 
2,560 
640 
ADD 
A AmAXnnnA 
□□ 
□So 
oooooa 
O0O 
OOD 
A AAAAAD 
A 
□□ □ 
160 
- AAA AAA □□ 
AA AA 
□□ 
40 
- 
A 
<40 
_ 
A 
0 
J 1 1 I I I I I L 
357 10 11 
Days 
_i 
1 4 
months 
Recombinant DNA Research, Volume 16 
[ 711 ] 
