Figure 4.5-B. Cotton rat serum anti-adenovirus titers following nasal 
administration of AvlCFl compared to Ad5 . The controls included administra- 
tion of vehicle and animals that are untreated but housed in proximity to 
the treated animals ("canary"). 
SERUM ANTI-ADENOVIRUS ANTIBODIES ASSOCIATED WITH SINGLE 
RESPIRATORY TRACT ADMINISTRATION OF ADENOVIRUS 
(Cotton Rats, CRC.008) 
Virus 
■ 
■ Canary 
▼ 
A Vehicle 
2,621,440 
A Ad5 (10 9 pfu) 
k. 
<D 
• AvlCFl (10 9 pfu) 
• 
655,360 
• 
>< 
■O 
o 
163,840 
— 
A# 
iAt 
c 
40,960 
— 
t 
• 
CO 
(/) 
• 
3 
k_ 
10,240 
••• 
> 
o 
2,560 
•A 
■ 
C 
<D 
T3 
CO 
640 
5 
■AAA 
A 
■ 
• 
c 
03 
160 
T 
■ 
■■ 
■ 
A 
E 
• 
3 
k_ 
O 
40 
■ 
0) 
<40 
i 
i 1 i i 
ili i i 
1 
// 1 
0 
3 
7 
14 
" 28 
Days after administration 
[712] 
Recombinant DNA Research, Volume 16 
