Figure 4.9-B. Theoretical recombination of AdCFTR with Ad5 . At the top is a 
schematic of AdCFTR (see section 2, figures 2.3-A, 2.3-B and appendix 1 for 
details). Below that is a schematic of Ad5 . If the genomes of AdCFTR and 
Ad5 were in the same cell and a homologous recombination event took place, 
the most likely product would be a replication competent Ad5 -based virus 
with an E3 deletion. This is the same as the Addl327 E3' Ad5 virus (see 
section 2 for details) . 
RECOMBINATION OF AdCFTR WITH Ad5 
AdCFTR 
Ad5 
El 
_L 
10 20 30 40 50 60 
Map units 
70 
80 
101 
90 100 
Addl327 
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Recombinant DNA Research, Volume 16 
