et al., 1992 and personal communication). 
Third, in transgenic mice in which the human CFTR cDNA is under the expres- 
sion of a lung-specific promoter (human surfactant protein C) , high level 
expression in bronchiolar and alveolar epithelial cells is observed. There 
were no changes in lung weight, morphology, somatic growth or reproductive 
capacity of these animals (Whitsett et al . , 1992). 
Recombinant DNA Research, Volume 16 
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