5.6.2-A 
BASELINE PERIOD 1 
Initial evaluation 
minimum of 1 week 
before day 1 . 
A 
Sample epithelium 
Left and right nostril 
Left and right bronchi 
Safety and efficacy parameters 2 
HIV 
Urine 
Routine 
Culture 
24 hr . . 
Sterility evaluation 
EKG 
Roentgenographic 
Chest X-ray 
Chest CT 
Scintigraphic 
Lung function 
Spirometry 
He dilution, DLCO 
Body box 
ABG 
Sputum 
Volume 
Culture 
Bronchoalveolar lavage. 
Nasal brush 
Bronchial brush 
Potential difference 
Vector-related 
Anti-Ad antibodies . 
Adenovirus culture. 
Adenovirus DNA . . 
Serum TNF 
General assessment 
Dyspnea index 
■ ■ 
B -j 
H 
General blood 
Ms? :> 
CBC, ESR 
■ ■ 
■ 
■ 
Clotting 
■ m 
■ 
Chemistry 
m m 
■ 
■ 
Other 
■ ■ 
"!£■, ■■■■ 
, St 
■ 
u 
General immunity 
■ ■ 
■ 
Culture 
■ ■ 
; ; 
Days 
5 . 10 
, ,Ti , ; , 1 1 . , 
.15 
<11.1 
% 1 
^ ■ 
■ 
; D 
PI 1 ?' 
6 ' ! 
: 
30 
m- 
■ ■ 
■ ■ 
■ 
■ ■ 
few?;"- 
. ■ I 
- • 
■ 
m- 
■ 
. 
— // 1 1 1 1 1 1 1 1 m ii " 1 1 1 1 1 1 1 1 " r rr n 1 rr 
- 0 5 1 0 1 5 20 25 30 
Recombinant DNA Research, Volume 16 
[751] 
